反応 #1476500

反応方程式

5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazole-2-methanol

acetic acid anhydride

→

{5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-ylmethyl}acetate

収率 74.4%

溶媒

methylbenzene

反応条件

後処理

1. 1
   温度refluxed for 2 hours
2. 2
   温度The reaction mixture is cooled
3. 3
   洗浄washed with a diluted ammonium hydroxide solution
4. 4
   その他the layers are separated
5. 5
   その他The organic phase is dried
6. 6
   ろ過filtered
7. 7
   その他evaporated
8. 8
   その他The residue is crystallized from a mixture of methylbenzene and 2,2'-oxybispropane (20:20 by volume)
9. 9
   ろ過The product is filtered off
10. 10
    その他dried

実験手順

A mixture of 1.9 parts of 5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazole-2-methanol, 1.55 parts of acetic acid anhydride and 45 parts of methylbenzene is stirred and refluxed for 2 hours. The reaction mixture is cooled, washed with a diluted ammonium hydroxide solution and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is crystallized from a mixture of methylbenzene and 2,2'-oxybispropane (20:20 by volume). The product is filtered off and dried, yielding 1.5 parts (74.4%) of {5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-ylmethyl}acetate; mp. 201.1° C.

出典