反応 #1476491

反応方程式

hydrochloric acid

sodium hydroxide

methyl {5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-yl}carbamate

→

5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-amine

溶媒

water

反応条件

後処理

1. 1
   温度refluxed for 3.50 hours
2. 2
   温度The reaction mixture is cooled
3. 3
   ろ過The precipitated product is filtered off
4. 4
   洗浄washed with water
5. 5
   温度After cooling
6. 6
   ろ過the product is filtered off
7. 7
   洗浄washed with ethanol and with 2,2'-oxybispropane
8. 8
   その他dried

実験手順

To a stirred solution of 4 parts of sodium hydroxide in 50 parts of water are added 4.7 parts of methyl {5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-yl}carbamate. The whole is stirred and refluxed for 3.50 hours. The reaction mixture is cooled and allowed to stand overnight. It is acidified with a hydrochloric acid solution 10 N. The precipitated product is filtered off, washed with water and boiled in ethanol. After cooling, the product is filtered off, washed with ethanol and with 2,2'-oxybispropane and dried, yielding 2.5 parts of 5-[4-(diphenylmethyl)-1-piperazinylmethyl]-1-methyl-1H-benzimidazol-2-amine; mp. 267.5° C.

出典