反応 #1470438

反応方程式

thionyl chloride

α-aminolauric acid

isopropanol

→

α-Aminolauric acid isopropyl ester

反応条件

後処理

1. 1
   温度to reflux for two hours
2. 2
   温度After cooling off to room temperature
3. 3
   濃縮the batch is completely concentrated by evaporation
4. 4
   workup.STIRRINGshaken out from aqueous sodium carbonate solution
5. 5
   その他The organic phase is dried on magnesium sulfate
6. 6
   ろ過filtered
7. 7
   濃縮concentrated by evaporation

実験手順

50 ml of isopropanol is stirred at 0° C. under argon and mixed drop by drop with 3.12 ml (41.6 mmol) of thionyl chloride. 30 minutes later, 7.40 g (34.4 mmol) of α-aminolauric acid is added in portions, stirred for one hour at room temperature and the batch then is allowed to reflux for two hours. After cooling off to room temperature, the batch is completely concentrated by evaporation, the residue is taken up in tert-butyl methyl ether and shaken out from aqueous sodium carbonate solution. The organic phase is dried on magnesium sulfate, filtered and concentrated by evaporation.

出典