反応 #1458421

反応方程式

dioxane

terbutyl pyrocarbonate

homoserine

cesium carbonate

→

Nα-Terbutyloxycarbonyl-DL-homoserine

溶媒

water

NaOH

反応条件

後処理

1. 1
   workup.ADDITIONwere added
2. 2
   温度the solution was cooled in an ice/water bath
3. 3
   workup.STIRRINGunder stirring in an ice-cold water bath for 1 hour
4. 4
   workup.WAITat room temperature for 5 hours
5. 5
   その他The solvent was subsequently removed under vacuum

実験手順

2 g of homoserine (16.78 mmol) were dissolved in 20 ml of water and to the solution 16.78 ml of 1 M NaOH and 3.006 g of cesium carbonate (9.23 mmol) were added. After stirring for 5 minutes, the solution was cooled in an ice/water bath. 60 ml of dioxane and terbutyl pyrocarbonate were then added. The reaction mixture was kept under stirring in an ice-cold water bath for 1 hour and thereafter at room temperature for 5 hours. The solvent was subsequently removed under vacuum. The dry residue was directly used in the next step.

出典