反応 #1456135

反応方程式

isonicotinic acid

N-hydroxysuccinimide

→

2,5-dioxopyrrolidin-1-yl isonicotinate

収率 98.7%

溶媒

THF

反応条件

後処理

1. 1
   ろ過The solid was filtered off
2. 2
   その他the solvent evaporated under reduced pressure
3. 3
   その他The residue was triturated with ethyl acetate and more solid
4. 4
   ろ過filtered off
5. 5
   濃縮The filtrates were concentrated under reduced pressure

実験手順

A mixture of isonicotinic acid (3 g), N-hydroxysuccinimide (2.79 g) and N,N-dicyclohexylcarbodiimide (5.52 g) was stirred in THF (200 mL) for 16 hours. The solid was filtered off and the solvent evaporated under reduced pressure. The residue was triturated with ethyl acetate and more solid filtered off. The filtrates were concentrated under reduced pressure gave 2,5-dioxopyrrolidin-1-yl isonicotinate (5.27 g). MS: 221 [MH]+.

出典