反応 #1453374

反応方程式

3-Bromomethyl-thiophene-2-carboxylic acid methyl ester

MeOH NH3

→

title compound

収率 86.0%

3-Aminomethyl-thiophene-2-carboxylic acid methyl ester

収率 86.0%

溶媒

DMF

反応条件

後処理

1. 1
   濃縮concentrated in vacuo
2. 2
   その他Purification of the residue by silica gel column chromatography
3. 3
   洗浄eluting with 95:5 and 93:7 DCM

実験手順

3-Bromomethyl-thiophene-2-carboxylic acid methyl ester (1.297 g, 5.54 mmol) is dissolved in DMF (30 mL) and MeOH/NH3 is added (30 mL). The reaction mixture is stirred at room temperature for 1 hour, and concentrated in vacuo. Purification of the residue by silica gel column chromatography eluting with 95:5 and 93:7 DCM:MeOH affords the title compound (0.82 g, 86%).

出典