反応 #1447133

反応方程式

dimethylamine

2-bromo-1-(4-bromophenyl)ethanone

→

title compound

収率 86.0%

1-(4-Bromophenyl)-2-(dimethylamino)ethanone

収率 86.0%

溶媒

methanol

tetrahydrofuran

反応条件

後処理

1. 1
   その他The solvent was removed by distillation
2. 2
   その他the residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100)

実験手順

A 2.0 M solution of dimethylamine (0.5 mmol) in methanol was added to a solution of 2-bromo-1-(4-bromophenyl)ethanone (114.5 mg, 0.41 mmol) in tetrahydrofuran (2 ml), and the mixture was stirred at room temperature for 15 min. The solvent was removed by distillation, and the residue was then purified by column chromatography on silica gel (hexane:ethyl acetate=10:1 to 0:100) to give 84.7 mg (yield 86%) of the title compound.

出典