反応 #1447123

反応方程式

1-(2-aminophenyl)-3-methylbutan-1-one

hydrazine hydrate

water

potassium hydroxide

→

[2-(3-methylbutyl)-phenyl]amine

収率 72.1%

溶媒

ethyl acetate

triethylene glycol

反応条件

後処理

1. 1
   洗浄The organic phase is again washed with water
2. 2
   乾燥dried over magnesium sulphate
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他Purification by column chromatography (cyclohexane/ethyl acetate 3:1)

実験手順

A solution comprising 8.0 g (0.045 mol) of 1-(2-aminophenyl)-3-methylbutan-1-one (X-1), 6.8 g (0.135 mol) of hydrazine hydrate and 7.6 g (0.135 mol) of potassium hydroxide in 90 ml of triethylene glycol is heated at 210° C. for 6 h. For work-up, water and ethyl acetate are added at room temperature. The organic phase is again washed with water, dried over magnesium sulphate and concentrated under reduced pressure. Purification by column chromatography (cyclohexane/ethyl acetate 3:1) gives 5.3 g (71.5% of theory) of [2-(3-methylbutyl)-phenyl]amine.

出典