反応 #1447102

反応方程式

KOtBu

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene

KOtBu

HCl

cyclobutanol

→

title compound

1-Bromo-4-cyano-3-cyclobutoxy-5-(4-ethyl-phenyl)-benzene

反応条件

後処理

1. 1
   workup.ADDITIONcharged with a stir bar
2. 2
   workup.ADDITIONis added
3. 3
   抽出The resulting mixture is extracted with ethyl acetate
4. 4
   乾燥the combined organic phases are dried (sodium sulphate)
5. 5
   その他the solvent is removed

実験手順

1-Bromo-4-cyano-3-fluoro-5-(4-ethyl-phenyl)-benzene (1.2 g) is added to a flask charged with a stir bar, KOtBu (0.5 g) and cyclobutanol (3.0 g). The solution is stirred at room temperature overnight, before another portion of KOtBu (0.2 g) is added. The solution is stirred for another 5 h and then neutralized with 1 M aqueous HCl solution. The resulting mixture is extracted with ethyl acetate, the combined organic phases are dried (sodium sulphate) and the solvent is removed to give the title compound.

出典