反応 #1447098

反応方程式

hydrochloric acid

N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide

→

title compound

4-Bromo-2-(4-ethyl-benzyl)-5-methoxy-phenylamine

溶媒

isopropanol

反応条件

後処理

1. 1
   温度The solution is heated
2. 2
   温度at reflux temperature for 8 h
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他to remove most of the alcohol
5. 5
   workup.ADDITIONAqueous NaHCO3 solution is added to the rest
6. 6
   抽出the resulting mixture is extracted twice with ethyl acetate
7. 7
   洗浄The combined organic extracts are washed with brine
8. 8
   乾燥dried (Na2SO4)
9. 9
   濃縮concentrated

実験手順

Half-concentrated hydrochloric acid (5 mL) is added to a solution of N-[4-bromo-2-(4-ethyl-benzyl)-5-methoxy-phenyl]-acetamide (2.8 g) in isopropanol (20 mL). The solution is heated at reflux temperature for 8 h and then concentrated under reduced pressure to remove most of the alcohol. Aqueous NaHCO3 solution is added to the rest and the resulting mixture is extracted twice with ethyl acetate. The combined organic extracts are washed with brine, dried (Na2SO4) and concentrated to give the title compound.

出典