反応 #1447093

反応方程式

water

Sodium methoxide

(2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone

sodium methoxide

→

(2-Bromo-4-methoxy-phenyl)-(4-ethyl-phenyl)-methanone

溶媒

DMF

反応条件

後処理

1. 1
   workup.ADDITIONis added
2. 2
   抽出the resulting mixture is extracted with ethyl acetate
3. 3
   乾燥The organic phase is dried (sodium sulphate)
4. 4
   その他the solvent is removed
5. 5
   その他the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1)

実験手順

Sodium methoxide (10.5 g) is added portionwise to (2-bromo-4-fluoro-phenyl)-(4-ethyl-phenyl)-methanone (43.0 g) dissolved in DMF (200 mL). The solution is stirred overnight, before another portion of sodium methoxide (5.5 g) is added. After another 3 h of stirring, water is added and the resulting mixture is extracted with ethyl acetate. The organic phase is dried (sodium sulphate), the solvent is removed and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 20:1->9:1).

出典