反応 #1447089

反応方程式

N-Boc-D-homophenylalanine Quinoline-3-amide

trifluoroacetic acid

→

title compound

収率 57.6%

D-Homophenylalanine Quinoline-3-amide

収率 57.6%

反応条件

後処理

1. 1
   濃縮The solution was concentrated to dryness
2. 2
   workup.ADDITIONtreated with diethyl ether (10 mL)
3. 3
   ろ過The solid was filtered
4. 4
   その他dried
5. 5
   workup.DISSOLUTIONIt was dissolved in water (180 mL)
6. 6
   ろ過the solid was filtered
7. 7
   その他dried

実験手順

N-Boc-D-homophenylalanine Quinoline-3-amide (2.6 g, 6.42 mmol, procedure 1A) was treated with trifluoroacetic acid (15 mL) at 25° C. for 1 hr. The solution was concentrated to dryness and treated with diethyl ether (10 mL). The solid was filtered and dried. It was dissolved in water (180 mL) and neutralized to pH=7.5 with saturated solution of sodium bicarbonate. The mixture was stirred for 1 hr and the solid was filtered and dried giving the title compound (1.30 g) as white solid.

出典