反応 #1442492

反応方程式

tri-n-butylstannylthiophene

3,6-dichloropyridazine

→

compound

収率 47.3%

3-(Thien-2-yl)-6-chloropyridazine

収率 47.3%

溶媒

DMF

反応条件

後処理

1. 1
   温度after cooling
2. 2
   workup.ADDITIONpoured onto water (100 mL)
3. 3
   その他A white precipitate was collected
4. 4
   洗浄washed several times with water
5. 5
   その他dried under vacuum
6. 6
   ろ過filtered
7. 7
   その他to afford 3.01 g of almost pure product
8. 8
   その他Finally, this solid was crystallized from MeOH—H2O

実験手順

A mixture of tri-n-butylstannylthiophene (6.26 g, 16.78 mmol), 3,6-dichloropyridazine (5.00 g, 33.56 mmol), tetrakis(triphenylphosphine)palladium(0) (0.20 g, 0.17 mmol) and few crystals of 1,2-ditert-butyl of 2,6-di-tert-butyl-4-methylphenolo in dry DMF (50 mL) was deareated twice with nitrogen. The reaction mixture was heated at 80° C. for 6 hours and, after cooling, poured onto water (100 mL). A white precipitate was collected, washed several times with water and dried under vacuum. This solid was taken up with ether (25 mL) and filtered to afford 3.01 g of almost pure product. Finally, this solid was crystallized from MeOH—H2O to give the pure target compound as white crystals (1.56 g, 7.90 mmol, 47.3% yield). Mp 155° C.; 1H NMR (CDCl3) δ 7.75 (1H, d, 2J=11.0), 7.68 (1H, d, 2J=3.6), 7.54 (1H, d, 2J=5.0), 7.51 (1H, d), 7.18 (1H, dd).

出典