反応 #1435731

反応方程式

hydrochloric acid

water

water

ethyl (2-chloro-6-fluorophenyl)acetoacetate

aminoimidazole hydrochloride

1,5-diazabicyclo[4.3.0]-5-nonene

→

5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine

溶媒

chloroform

N,N-dimethylformamide

反応条件

後処理

1. 1
   温度to cool
2. 2
   ろ過the precipitate was filtered

実験手順

A mixture of 1.29 g of ethyl (2-chloro-6-fluorophenyl)acetoacetate, 0.60 g of aminoimidazole hydrochloride, 1.24 g of 1,5-diazabicyclo[4.3.0]-5-nonene (DBN) and 5 ml of N,N-dimethylformamide was heated at 100° C. for 14 hours. The reaction mixture was allowed to cool, and chloroform and water were added thereto. To the separated water layer, conc. hydrochloric acid was added and the precipitate was filtered, which was followed to subject to silica gel chromatography to give 0.16 g of 5-hydroxy-6-(2-chloro-6-fluorophenyl)-7-methylimidazo[1,2-a]pyrimidine.

出典