反応 #1435697

反応方程式

ethanol

cysteine hydrochloride

maltose

Ethanol

pyridine

→

2-(1,2,4,5-Tetrahydroxy-3-Glucopyranosyloxypentyl) Thiazolidine-4-Carboxylic acid

溶媒

water

反応条件

後処理

1. 1
   workup.WAITthe solution was left
2. 2
   その他was formed
3. 3
   その他The solvent was removed by decantation
4. 4
   workup.DISSOLUTIONthe precipitate was dissolved in 100 ml of water
5. 5
   その他After the insoluble matters were removed by filtration
6. 6
   その他condensed to about 30 ml
7. 7
   workup.WAITthe solution was then left
8. 8
   その他to stand in a refrigerator overnight
9. 9
   ろ過The produced crystals were collected by filtration
10. 10
    workup.DISSOLUTIONThe crystals were then dissolved in water again
11. 11
    その他the insoluble matters were removed by filtration
12. 12
    その他condensed, and ethanol
13. 13
    workup.ADDITIONwas added to the solution
14. 14
    その他recrystallization
15. 15
    ろ過The produced crystals were collected by filtration
16. 16
    その他dried under reduced pressure
17. 17
    その他to obtain 2.2 g of a white powder (molar yield based on cysteine: 4.9%)

実験手順

17.56 Grams (100 mmol) of cysteine hydrochloride and 34.20 g (100 mmol) of maltose were dissolved in 35 ml of pure water, 8.36 ml (100 mmol) of pyridine was then added thereto, and the resulting solution was stirred at room temperature for 72 hours. 300 Milliliters of ethanol was added to the stirred solution, and the solution was left to stand in a refrigerator, whereby a paste-like precipitate was formed. The solvent was removed by decantation, and the precipitate was dissolved in 100 ml of water. After the insoluble matters were removed by filtration, the remaining solution was condensed to about 30 ml. Ethanol was continuously added to the condensed solution until a precipitate was about to appear, and the solution was then left to stand in a refrigerator overnight. The produced crystals were collected by filtration. The crystals were then dissolved in water again, the insoluble matters were removed by filtration, the resulting solution was condensed, and ethanol was added to the solution to cause recrystallization. The produced crystals were collected by filtration and dried under reduced pressure to obtain 2.2 g of a white powder (molar yield based on cysteine: 4.9%).

出典