反応 #1435687

反応方程式

benzyl cyanoformate

diethylenetriamine

triethylamine

→

Bis[2-(benzyloxycarbonylamino)-ethyl]-amine

溶媒

dichloromethane

dichloromethane

反応条件

後処理

1. 1
   濃縮concentration
2. 2
   その他by evaporation
3. 3
   洗浄the organic phase is washed with sodium carbonate solution
4. 4
   乾燥dried with sodium sulfate
5. 5
   workup.ADDITIONThe filtrate is mixed with hexane
6. 6
   ろ過the precipitate is filtered out
7. 7
   その他dried

実験手順

51.5 g (500 mmol) of diethylenetriamine and 139 ml (1 mol) of triethylamine are dissolved in dichloromethane and mixed at −20° C. with 161 g of benzyl cyanoformate (Fluka) in dichloromethane and then stirred overnight at room temperature. After the reaction is completed, concentration by evaporation is performed during draw-off, the residue is taken up in diethyl ether, the organic phase is washed with sodium carbonate solution and dried with sodium sulfate. The filtrate is mixed with hexane, the precipitate is filtered out and dried.

出典