反応 #1435685

反応方程式

3,3′-(4-methoxy-5-methyl-1,3-phenylene)bis-(1,3-oxazolidin-2-one)

KOH

HCl

→

2,4-Bis[(2-hydroxyethyl)amino]-6-methylanisole

溶媒

water

反応条件

後処理

1. 1
   抽出extracted several times with ethyl acetate
2. 2
   その他The combined ethyl acetate phases were evaporated on a Rotavapor
3. 3
   workup.DISTILLATIONdistilled in a Kugelrohr (250–290° C., 0.08 mbar)

実験手順

33.5 g of 3,3′-(4-methoxy-5-methyl-1,3-phenylene)bis-(1,3-oxazolidin-2-one) were heated under reflux in 500 ml of 20% strength KOH for 10 h. The mixture was cooled to room temperature and poured onto 1.5 l of iced water. The mixture was then neutralized with HCl and extracted several times with ethyl acetate. The combined ethyl acetate phases were evaporated on a Rotavapor and then distilled in a Kugelrohr (250–290° C., 0.08 mbar).

出典