反応 #1394

反応方程式

trimethylpyruvic acid sodium salt

hydroxylamine hydrochloride

→

trimethylpyruvic acid oxime

収率 81.2%

溶媒

water

反応条件

後処理

1. 1
   その他The product crystallized out
2. 2
   温度during slow cooling under agitation
3. 3
   ろ過After 1.5 h agitation in an ice bath the crystals were filtered off
4. 4
   洗浄washed with 150 ml ice water
5. 5
   その他dried in a vacuum at 60° C.
6. 6
   乾燥further dried in a vacuum desiccator over phosphorus pentaoxide to constant weight

実験手順

163 g (1 mole) 93.5% trimethylpyruvic acid sodium salt and 69.5 g (1 mole) hydroxylamine hydrochloride were dissolved at 40° C. in 450 ml water. The product crystallized out during slow cooling under agitation. After 1.5 h agitation in an ice bath the crystals were filtered off, washed with 150 ml ice water, dried in a vacuum at 60° C., and then further dried in a vacuum desiccator over phosphorus pentaoxide to constant weight. 117.8 g trimethylpyruvic acid oxime (81% yield) in the form of colorless crystals were obtained.

出典