反応 #1381

反応方程式

Methyl 2-methyl-3-nitrobenzoate

→

methyl 2-methyl-3-aminobenzoate

収率 101.6%

溶媒

acetic acid

反応条件

後処理

1. 1
   その他at room temperature
2. 2
   ろ過the catalyst is filtered off
3. 3
   濃縮The reaction mixture is concentrated
4. 4
   workup.ADDITIONis added water
5. 5
   抽出followed by extraction with dichloromethane
6. 6
   濃縮The solvent is concentrated

実験手順

Methyl 2-methyl-3-nitrobenzoate (10.0 g) is dissolved in acetic acid (50 ml) and thereto 5% Pd-C (1 g) is added to carry out catalytic reduction at room temperature under 1 atm. After 1.5 hours, the catalyst is filtered off. The reaction mixture is concentrated, and thereto is added water, and the mixture is made alkaline with potassium carbonate, followed by extraction with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-aminobenzoate (8.6 g).

出典