反応 #1380

反応方程式

2-methyl-3-nitrobenzoic acid

methanol

thionyl chloride

→

methyl 2-methyl-3-nitrobenzoate

反応条件

後処理

1. 1
   温度After reflux for 2 hours
2. 2
   抽出extracted with dichloromethane
3. 3
   濃縮The solvent is concentrated

実験手順

To 2-methyl-3-nitrobenzoic acid (10.0 g) is added methanol (100 ml) and thereto thionyl chloride (8 ml) is added dropwise at room temperature. After reflux for 2 hours, the reaction mixture is poured into ice-water and extracted with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-nitrobenzoate (10.8 g).

出典