反応 #1379892

反応方程式

2,3-bis-tert-butoxycarbonylamino propionic acid benzyl ester

HCl

→

2,3-Diamino-propionic acid trihydrochloride

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The solvent was removed under vacuum
2. 2
   workup.ADDITIONthe mixture was diluted with ethyl acetate (100 ml) and water (50 ml)
3. 3
   その他The layers were separated
4. 4
   その他the aqueous layer was evaporated to dryness (1.23 g of a foam/syrup)

実験手順

A solution of 2,3-bis-tert-butoxycarbonylamino propionic acid benzyl ester (1.8 g), 4N aqueous HCl (40 ml), and acetonitrile (50 ml) was stirred for 18 hours at room temperature. The solvent was removed under vacuum, and the mixture was diluted with ethyl acetate (100 ml) and water (50 ml) and stirred for 15 minutes. The layers were separated and the aqueous layer was evaporated to dryness (1.23 g of a foam/syrup). 1H NMR (300 MHz): 3.2-3.5 (m, 2H), 4.2-4.35 (m, 1H), 5.13-5.25 (q, 2H, J=11.8, 3.1 Hz).

出典