反応 #1379886

反応方程式

2-chloro-3-nitro-6-methoxypyridine

3-methylamino-1,2-dihydroxypropane

→

yellow powder

収率 87.1%

3-[(6-methoxy-3-nitro-2-pyridyl)methylamino]propane-1,2-diol

収率 87.1%

溶媒

ethanol

反応条件

後処理

1. 1
   温度The mixture is refluxed for 2 hours
2. 2
   workup.STIRRINGwith stirring
3. 3
   その他The precipitate formed
4. 4
   ろ過is filtered off by suction
5. 5
   その他dried under vacuum to constant weight

実験手順

4 g (0.0219 mol) of the product 2-chloro-3-nitro-6-methoxypyridine, 50 ml of ethanol and 4.15 ml (0.0438 mol) of 3-methylamino-1,2-dihydroxypropane are placed in a fully equipped round-bottomed flask. The mixture is refluxed for 2 hours with stirring and is then poured onto an ice/water mixture with stirring. The precipitate formed is filtered off by suction and dried under vacuum to constant weight. 4.74 g of yellow powder are obtained, ie a yield of 87.1%.

出典