反応 #1375831

反応方程式

1-methyl-3-indole acetic acid

sulfuric acid

methanol

→

yellow oil

methyl 2-(1-methyl-3-indolyl)acetate

反応条件

後処理

1. 1
   濃縮The mixture was concentrated by evaporation
2. 2
   workup.DISSOLUTIONthe residue was dissolved in dichloromethane
3. 3
   workup.ADDITIONpoured into a solution of aqueous saturated sodium bicarbonate
4. 4
   抽出The mixture was then extracted with dichloromethane and excess magnesium sulfate
5. 5
   workup.ADDITIONwas added to the extract
6. 6
   workup.DISTILLATIONThe product was purified by distillation

実験手順

To a solution of 20 g of 1-methyl-3-indole acetic acid in 120 mL of methanol was added 0.5 mL of concentrated sulfuric acid and the mixture was stirred at room temperature for 18 hours. The mixture was concentrated by evaporation and the residue was dissolved in dichloromethane, and then poured into a solution of aqueous saturated sodium bicarbonate. The mixture was then extracted with dichloromethane and excess magnesium sulfate was added to the extract. The product was purified by distillation to give 25 g of yellow oil.

出典