反応 #1372

反応方程式

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

acetic anhydride

triethoxymethane

→

ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate

収率 90.0%

反応条件

後処理

1. 1
   温度the mixture is refluxed for 1 hour
2. 2
   濃縮After concentrating

実験手順

To ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.2 g) are added acetic anhydride (3.0 g) and triethoxymethane (2.7 g) and the mixture is refluxed for 1 hour. After concentrating, ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (3.5 g) is obtained.

出典