反応 #1371056

反応方程式

diphenyliodonium chloride

2-ethyl-4,5-dichloro-6-methoxyindan-1,3-dione

benzene

Potassium tert-butoxide

→

2-ethyl-2-phenyl-4,5-dichloro-6-methoxyindan-1,3-dione

溶媒

water

tert-butanol

tert-butanol

反応条件

後処理

1. 1
   温度refluxing
2. 2
   温度refluxing
3. 3
   workup.WAITis continued for an additional 2 hours
4. 4
   温度The reaction mixture is cooled to 25°
5. 5
   濃縮the mixture concentrated to dryness in vacuo

実験手順

Potassium tert-butoxide (8.4 g.) dissolved in tert-butanol (300 ml.) is added to a refluxing solution of 2-ethyl-4,5-dichloro-6-methoxyindan-1,3-dione (1.3 g) in tert-butanol (400 ml.)-benzene (200 ml.) and refluxing is continued for 15 min., then diphenyliodonium chloride (19.0 g.) is added and refluxing is continued for an additional 2 hours. The reaction mixture is cooled to 25°, 300 ml. water added, and the mixture concentrated to dryness in vacuo to give 2-ethyl-2-phenyl-4,5-dichloro-6-methoxyindan-1,3-dione.

出典