反応 #1371

反応方程式

diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate

p-toluenesulfonic acid

→

ethyl 2-methyl-3,4,6-trifluorobenzoylacetate

収率 82.6%

溶媒

water

反応条件

後処理

1. 1
   温度the mixture is refluxed for 2.5 hours
2. 2
   温度After cooling
3. 3
   抽出the resultant is extracted with diethyl ether
4. 4
   乾燥the extract is dried over magnesium sulfate
5. 5
   濃縮concentrated

実験手順

To diethyl 2-methyl-3,4,6-trifluorobenzoylmalonate (5.1 g) are added water (20 ml) and p-toluenesulfonic acid (30 mg) and the mixture is refluxed for 2.5 hours. After cooling, the resultant is extracted with diethyl ether, and the extract is dried over magnesium sulfate and concentrated to give ethyl 2-methyl-3,4,6-trifluorobenzoylacetate (3.3 g).

出典