反応 #1367

反応方程式

2-methylthiomethyl-3,4,6-trifluoroaniline

→

2-methyl-3,4,6-trifluoroaniline

収率 71.3%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過After the catalyst is filtered off
2. 2
   workup.ADDITIONthe filtrate is added with water
3. 3
   抽出extracted with dichloromethane
4. 4
   乾燥The is dried over magnesium sulfate
5. 5
   濃縮concentrated

実験手順

To 2-methylthiomethyl-3,4,6-trifluoroaniline (22.2 g) are added ethanol (400 ml) and Raney nickel (200 g) and the mixture is stirred at room temperature for 30 minutes. After the catalyst is filtered off, the filtrate is added with water and extracted with dichloromethane. The is dried over magnesium sulfate and concentrated to give 2-methyl-3,4,6-trifluoroaniline (12.3 g).

出典