反応 #1355

反応方程式

3-(2-bromophenyl)-2-propylpropionic acid

thionyl chloride

→

crude product

3-(bromophenyl)-2-n-propylpropionyl chloride

反応条件

後処理

1. 1
   その他A 500-ml three-necked round flask equipped with a stirring bar
2. 2
   温度the mixture was heated
3. 3
   温度under reflux for 2 hours
4. 4
   その他Then, the excess thionyl chloride was removed by a single distillation
5. 5
   workup.DISTILLATIONthe distillation of the residue under reduced pressure

実験手順

A 500-ml three-necked round flask equipped with a stirring bar, a Dimroth condenser, a thermometer and a NaOH trap was charged with 277 mmol of 3-(2-bromophenyl)-2-propylpropionic acid and 200 ml of thionyl chloride, and the mixture was heated under reflux for 2 hours. Then, the excess thionyl chloride was removed by a single distillation, and the distillation of the residue under reduced pressure gave 77.4 g of a crude product having a boiling point of 130° to 135° C./1 mmHg as a pale brown transparent liquid. This acid chloride was used in the next reaction without further purification

出典