反応 #1354501

反応方程式

4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde

sodium pyruvate

sodium carbonate

water

→

(E)-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzylidenepyruvic acid

収率 44.5%

溶媒

methanol

反応条件

後処理

1. 1
   温度under reflux
2. 2
   濃縮The reaction mixture was concentrated
3. 3
   温度under reflux to about ⅓ of the initial volume
4. 4
   抽出The concentrate was subjected to extraction with ethyl acetate
5. 5
   ろ過Resulting crystalline precipitate was collected by filtration

実験手順

A mixture of 4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzaldehyde (2.9 g), sodium pyruvate (3.3 g), sodium carbonate (3.2 g), water (80 ml) and methanol (80 ml) was stirred for 6 hours under reflux. The reaction mixture was concentrated under reflux to about ⅓ of the initial volume. The concentrate was subjected to extraction with ethyl acetate. The aqueous layer was acidified with conc. HCl. Resulting crystalline precipitate was collected by filtration to obtain (E)-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzylidenepyruvic acid (1.6 g, 44%). Recrystallization from chloroform-methanol gave colorless needles, m.p.197-198° C.

出典