反応 #1352

反応方程式

3-(2-biphenylyl)-2-ethylpropionic acid

thionyl chloride

→

crude product

収率 106.3%

3-(2-biphenylyl)-2-ethylpropionyl chloride

収率 106.3%

反応条件

後処理

1. 1
   その他A 100-ml three-necked round flask equipped with a stirring bar
2. 2
   温度under reflux for 2.5 hours under a nitrogen atmosphere
3. 3
   workup.DISTILLATIONthe unreacted thionyl chloride was distilled off under reduced pressure

実験手順

A 100-ml three-necked round flask equipped with a stirring bar, a Dimroth condenser, a thermometer and a NaOH trap was charged with 13.3 g (52.4 mmol) of 3-(2-biphenylyl)-2-ethylpropionic acid and 25.9 ml (355 mmol) of thionyl chloride, and the resulting mixture was stirred under reflux for 2.5 hours under a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 15.2 g of a crude product as a yellow-orange liquid. The thus obtained acid chloride was used in the next reaction without further purification.

出典