反応 #1351530

反応方程式

NaHCO3

Na2CO3

4-(4-aminophenyl)-butyric acid

HCl

→

40

収率 91.0%

Methyl-4-(4-aminophenyl)-butanoate

収率 91.0%

溶媒

MeOH

反応条件

後処理

1. 1
   その他The solvent was evaporated under reduced pressure
2. 2
   抽出the aqueous phase was extracted several times with CH2Cl2
3. 3
   その他The crude material was purified by flash chromatography

実験手順

To a solution of 4-(4-aminophenyl)-butyric acid (5 g, 27.90 mmol) in MeOH (100 mL) at room temperature was added HCl conc. (37% 15 mL). The resulting mixture was stirred overnight at 50° C. then treated with a saturated aqueous solution NaHCO3 and Na2CO3 solid until pH 9. The solvent was evaporated under reduced pressure then the aqueous phase was extracted several times with CH2Cl2. The crude material was purified by flash chromatography using CH2Cl2/MeOH as solvent mixture yielding 40 (4.93 g, 91%) as orange solid.

出典