反応 #1350594

反応方程式

EDC

2-methylamino-4-methylbenzothiazole-5-carboxylic acid

1-methyl-5-hydroxypyrazole

acetonitrile

→

1-Methylpyrazol-5-yl 2-Methylamino-4-methylbenzothiazole-5-carboxylate

溶媒

water

triethylamine

反応条件

後処理

1. 1
   抽出the mixture was extracted with ethyl acetate
2. 2
   洗浄The organic phase was washed
3. 3
   その他dried
4. 4
   その他the product was then purified by crystallization

実験手順

3.1 g of 2-methylamino-4-methylbenzothiazole-5-carboxylic acid (0.014 mol) and 1.4 g of 1-methyl-5-hydroxypyrazole (0.015 mol) were dissolved in 110 ml of abs. acetonitrile and admixed with 2.67 g of EDC (0.014 mol), 1,2 ml of triethylamine and a catalytic amount of DMAP. After the reaction had ended, the solution was poured into water and the mixture was extracted with ethyl acetate. The organic phase was washed and dried, and the product was then purified by crystallization. Yield: 2.2 g (52%).

出典