反応 #1350592

反応方程式

NaNO2

methyl 2-amino-4-methylbenzothiazole-5-carboxylate

KOH

HCl

→

4-Methylbenzothiadiazole-5-carboxylic Acid

反応条件

後処理

1. 1
   その他at 0-10° C
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The extract was washed
4. 4
   その他dried
5. 5
   その他the product was obtained

実験手順

5 g of methyl 2-amino-4-methylbenzothiazole-5-carboxylate (0.02 mol) in 28.6 g of 50% strength KOH were stirred at 120° C. for 4 h. The mixture was then neutralized with 10% strength HCl and admixed with an excess of 40% strength NaNO2 solution at 0-10° C. The reaction mixture was acidified and extracted with ethyl acetate. The extract was washed and dried, and the product was obtained by stripping off the solvent. Yield: 1.3 g (28%).

出典