反応 #1350591

反応方程式

EDC

3-chloro-4-methylbenzothiazol-5-carboxylic acid

1-methyl-5-hydroxypyrazole

acetonitrile

→

1-Methylpyrazol-5-yl 3-Chloro-4-methylbenzothiazole-5-carboxylate

溶媒

water

triethylamine

反応条件

後処理

1. 1
   抽出the product was extracted with ethyl acetate
2. 2
   洗浄The organic phase was washed
3. 3
   その他dried
4. 4
   その他the product was purified by crystallization/column chromatography

実験手順

1 g of 3-chloro-4-methylbenzothiazol-5-carboxylic acid (4.4 mol) and 0.46 g of 1-methyl-5-hydroxypyrazole (4.7 mol) were dissolved in 50 ml of abs. acetonitrile and admixed with 1 g of EDC, 0.7 ml of triethylamine and a catalytic amount of DMAP. After the reaction had ended, the solution was poured into water and the product was extracted with ethyl acetate. The organic phase was washed and dried and the product was purified by crystallization/column chromatography. Yield: 0.22 g (16%).

出典