反応 #1350590

反応方程式

HCl

NaNO2

methyl 2-amino-4-methylbenzothiazole-5-carboxylate

→

Methyl 2-chloro-4-methylbenzothiazole-5-carboxylate

溶媒

water

phosphoric acid

反応条件

後処理

1. 1
   温度After cooling
2. 2
   ろ過the residue was filtered off with suction
3. 3
   洗浄washed with water
4. 4
   その他dried
5. 5
   その他The product was purified by silica gel column chromatography

実験手順

At −8° C., a solution of 9.3 g of NaNO2 (0.14 mol) in 10 ml of water was added dropwise to a solution of 5 g of methyl 2-amino-4-methylbenzothiazole-5-carboxylate (0.02 mol) in 150 ml of phosphoric acid. At 5° C., a solution of 3 g of CuCl and 12 ml of conc. HCl was then added dropwise. The reaction mixture was heated to 100° C. After cooling, the residue was filtered off with suction, washed with water and dried. The product was purified by silica gel column chromatography.

出典