反応 #1350588

反応方程式

15-crown-5

sulfuric acid

methyl 3-amino-2-methylbenzoate

sodium thiocyanate

→

N-(2-Methyl-3-methoxycarbonylphenyl)thiourea

溶媒

chlorobenzene

反応条件

後処理

1. 1
   温度After cooling
2. 2
   ろ過the solid was filtered off with.suction,
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

90.7 g of methyl 3-amino-2-methylbenzoate (0.55 mol) were dissolved in 510 ml of chlorobenzene and, at −5° C., admixed with 14 ml of conc. sulfuric acid and 49 g of sodium thiocyanate (0.6 mol). 2 ml of 15-crown-5 were then added, and the reaction mixture was heated at 100° C. for 13 h. After cooling, the solid was filtered off with.suction, washed with water and dried. Yield: 104.8 g (85%).

出典