反応 #1350584

反応方程式

formic acid

methyl 3-amino-2-methyl-4-methylsulfanylbenzoate

→

Methyl 3-Formamidyl-2-methyl-4-methylsulfanylbenzoate

溶媒

acetic anhydride

反応条件

後処理

1. 1
   温度to cool
2. 2
   抽出the mixture was extracted exhaustively with methylene chloride
3. 3
   洗浄The organic phases were washed
4. 4
   その他dried
5. 5
   その他the solvent was subsequently removed

実験手順

At 40° C., 4.75 g of methyl 3-amino-2-methyl-4-methylsulfanylbenzoate (0.05 mol) were added a little at a time to a mixture of 30 ml of acetic anhydride and 2.2 g of formic acid (0.05 mol). After 5 h, the solution was allowed to cool and poured into ice-water, and the mixture was extracted exhaustively with methylene chloride. The organic phases were washed and dried, and the solvent was subsequently removed. Yield: 4.7 g (0.044 mol).

出典