反応 #1350572

反応方程式

4-(trifluoromethoxy)benzylamine

triphosgene

3-(3-aminophenyl)4-bromo-1-methylpyrazole

triethylamine

→

title compound

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][{(4-trifluoromethoxyphenyl)methyl}amino]carboxamide

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   濃縮concentrated

実験手順

To a stirred solution of triphosgene (12 mg, 0.04 mmol) in CH2Cl2 (0.5 mL) was added dropwise a solution of 3-(3-aminophenyl)4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (33 μL, 0.24 mmol) in CH2Cl2 (0.5 mL). After 1 h, 4-(trifluoromethoxy)benzylamine (23 mg, 0.12 mmol) was added. The reaction mixture was stirred for 16 h and concentrated. Chromatography on flash silica (75% EtOAc/hexane) gave the title compound as a colourless solid (38 mg, 68%), m.p. 144.6-145.8° C. (EtOAc/hexane).

出典