反応 #1350571

反応方程式

4-(trifluoromethoxy)benzoyl chloride

3-(3-aminophenyl)-4-bromo-1-methylpyrazole

triethylamine

→

title compound

収率 76.0%

N-[3-(4-bromo-1-methylpyrazol-3-yl)phenyl][4-trifluoromethoxyphenyl]carboxamide

収率 76.0%

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   濃縮concentrated

実験手順

To 4-(trifluoromethoxy)benzoyl chloride (19 μL, 0.12 mmol) in CH2Cl2 (1 mL) was added dropwise a solution of 3-(3-aminophenyl)-4-bromo-1-methylpyrazole (30 mg, 0.12 mmol) and triethylamine (17 μL, 0.12 mmol) in CH2Cl2 (0.5 mL). The reaction mixture was stirred for 16 h and concentrated. Chromatography on flash silica (50% EtOAc/hexane) gave the title compound as a colourless solid (40 mg, 76%), m.p. 138.6-139.6° C. (EtOAc/hexane).

出典