反応 #1350569

ord-a9de046f2e654de5b5db01ec8e69c814

反応方程式

Homogentisic acid

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2cc(O)ccc2O1

tocol

H3PO4

Cc1c(O)cc2c(c1C)O[C@](C)(CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC2

γ-tocopherol

Homogentisic acid

→

$C/C(=C\Cc1cc(O)c(C)c(C)c1O)CCC[C@H](C)CCC[C@H](C)CCCC(C)C$

2,3-dimethyl-5-phytylquinol

$C/C(=C\Cc1cc(O)cc(C)c1O)CCC[C@H](C)CCC[C@H](C)CCCC(C)C$

2-methyl-6-phytylquinol

$C/C(=C\COP(=O)([O-])OP(=O)([O-])[O-])CCC[C@H](C)CCC[C@H](C)CCCC(C)C$

Phytyl pyrophosphate

反応物

試薬

なし

反応条件

詳細条件

See reaction.notes.procedure_details.

実験手順

Homogentisic acid in 0.1% H3PO4 (specific radioactivity 40 Ci/mmol). Phytyl pyrophosphate was synthesized as described by Joo, et al. (1973) Can J. Biochem. 51: 1527. 2-methyl-6-phytylquinol and 2,3-dimethyl-5-phytylquinol were synthesized as described bySoll, et al. (1980) Phytochemistry 19: 215. Homogentisic acid, α, β, δ, and γ-tocopherol, and tocol, were purchased commercially.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US06541259B1uspto-grants-2003_04