反応 #1350564

反応方程式

N-cyclooctyl pyrrolidine

butyl iodide

butyl iodide

potassium bicarbonate

→

N-butyl-N-cyclooctylpyrrolidinium iodide

収率 90.0%

溶媒

methanol

反応条件

後処理

1. 1
   温度The reaction mixture was refluxed
2. 2
   workup.STIRRINGthe mixture was stirred
3. 3
   温度at refluxing temperature for an additional 36 hours
4. 4
   濃縮The reaction mixture was concentrated at reduced pressure on a rotary evaporator
5. 5
   その他to give an off-white colored solid material
6. 6
   洗浄The solids were rinsed several times with chloroform
7. 7
   ろ過filtered after each rinse
8. 8
   濃縮concentrated
9. 9
   その他to give a white powder whose NMR data
10. 10
    その他The reaction afforded 109 gm

実験手順

To a solution of 60 gms. (0.33 mole) of N-cyclooctyl pyrrolidine in 600 ml. anhydrous methanol, 150 gm. (0.825 mole) of butyl iodide was added. The reaction mixture was refluxed while stirring for four days. Then an additional equivalent of butyl iodide and one equivalent (33 gm., 0.33 mole) of potassium bicarbonate were added and the mixture was stirred at refluxing temperature for an additional 36 hours. The reaction mixture was concentrated at reduced pressure on a rotary evaporator to give an off-white colored solid material. The solids were rinsed several times with chloroform and filtered after each rinse. All the chloroform rinses were combined and concentrated to give a white powder whose NMR data were acceptable for the desired quaternary ammonium iodide salt. The reaction afforded 109 gm. (90% yield) of N-butyl-N-cyclooctylpyrrolidinium iodide. The iodide salt was purified by recrystallization by completely dissolving the iodide salt in acetone, and then precipitating by the addition of ethyl ether to the acetone solution. This procedure gave 98 gms. of white powder with very clean 1H and 13C-NRM spectra.

出典