反応 #1350324

反応方程式

6-(3-piperazinylpropyl)-3,4-dihydrocarbostyril

p-nitroaniline

potassium carbonate

→

6-{3-[4-(4-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril

溶媒

3-methoxybutanol

反応条件

後処理

1. 1
   温度refluxed
2. 2
   温度by heating for 5 hours
3. 3
   workup.ADDITIONThen 3 g of activated carbon was added to the reaction mixture
4. 4
   ろ過filtered with Celite
5. 5
   濃縮the mother liquor was concentrated under a reduced pressure
6. 6
   その他to obtain a residue
7. 7
   その他The residue was purified by a silica-gel chromatography
8. 8
   その他recrystallized from isopropanol

実験手順

2.87 Grams of 6-(3-piperazinylpropyl)-3,4-dihydrocarbostyril, 2.0 g of p-nitroaniline, 0.8 g of potassium carbonate and 0.2 g of copper powder were mixed in 80 ml of 3-methoxybutanol and refluxed by heating for 5 hours. Then 3 g of activated carbon was added to the reaction mixture and filtered with Celite, then the mother liquor was concentrated under a reduced pressure to obtain a residue. The residue was purified by a silica-gel chromatography and recrystallized from isopropanol to obtain 0.55 g of 6-{3-[4-(4-nitrophenyl)-1-piperazinyl]propyl}-3,4-dihydrocarbostyril in yellow needle-like crystals, having the melting point of 189°-192° C.

出典