反応 #1340618

反応方程式

4-formylbenzoic acid

2-fluoroaniline

decaborane

→

47c

収率 99.2%

4-(((2-fluorophenyl)amino)methyl)benzoic acid

収率 99.2%

溶媒

MeOH

反応条件

後処理

1. 1
   濃縮The mixture was concentrated
2. 2
   その他purified by preparative reverse-phase chromatography

実験手順

A mixture of 4-formylbenzoic acid 47a (3.33 mmol, 500 mg), 2-fluoroaniline 47b (3.33 mmol, 370 mg), and decaborane (1 mmol, 122 mg) in 8 mL of MeOH was stirred at room temperature for 15 min. The mixture was concentrated and purified by preparative reverse-phase chromatography to afford 0.81 g (99%) of 47c.

出典