反応 #1340607

反応方程式

hydrogen

(3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-cyclopropylpyrrolidine

→

title compound

(3S,4S)-3-(tert-Butoxycarbonyl)amino-4-cyclopropylpyrrolidine

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過After filtration
2. 2
   濃縮the filtrate was concentrated under reduced pressure

実験手順

A 10% palladium carbon catalyst (50 mg) was added to a solution of (3S,4S)-1-benzyloxycarbonyl-3-(tert-butoxycarbonyl)amino-4-cyclopropylpyrrolidine (408 mg, 1.13 mmol) in ethanol (5 mL), followed by stirring in a hydrogen atmosphere under an ordinary pressure at 45° C. for 12 hours. After filtration, the filtrate was concentrated under reduced pressure, to thereby yield the title compound as a colorless oily substance (255 mg, quantitative amount). The product was employed, without further purification, in the subsequent step.

出典