反応 #1340591

反応方程式

hydrazine monohydrate

N3-Phe-H

H-Leu-OMe

Boc-Leu-H

HCTU

→

Compound 38

N3-Phe-Leu-Leu-NHNH2

溶媒

MeOH

toluene

反応条件

後処理

1. 1
   その他This compound was synthesized via general Boc-

実験手順

This compound was synthesized via general Boc-based peptide coupling procedures using HCTU from H-Leu-OMe, Boc-Leu-H and N3-Phe-H. The last step involved the introduction of the hydrazide by stirring of a mixture containing tripeptide N3-Phe-Leu-Leu-OMe (1.51 g, 3.49 mmol) and hydrazine monohydrate (30 eq., 105 mmol, 5.1 mL) in MeOH (30 mL) for 15 hours at room temperature. Compound 38 was obtained after coevaporation of the mixture with toluene (3×) as a colourless solid (yield: 1.51 g, 3.49 mmol, quant.). LC-MS: Rt (min): 6.87 (ESI-MS (m/z): 432.13 (M+H+)).

出典