反応 #1340588

反応方程式

N-[2,6-diethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethylethyl)phenyl]-3-nitro-4-(1,2,4-triazol-1-yl)benzamide

→

3-amino-N-[2,6-diethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethylethyl)phenyl]-4-(1,2,4-triazol-1-yl)benzamide

収率 74.0%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The reaction mixture was filtered
2. 2
   濃縮the filtrate was concentrated
3. 3
   その他The residue was purified by column chromatography on silica gel (eluent: cyclohexane/ethyl acetate 1:4)
4. 4
   その他to give Compound No

実験手順

A solution of N-[2,6-diethyl-4-(1,2,2,2-tetrafluoro-1-trifluoromethylethyl)phenyl]-3-nitro-4-(1,2,4-triazol-1-yl)benzamide (473 mg, 0.89 mmol) (Example I2) in ethanol (9 ml) was charged with palladium on carbon (10%) (140 mg, 0.13 mmol) and was stirred under a atmosphere of hydrogen for 15 hours. The reaction mixture was filtered and the filtrate was concentrated. The residue was purified by column chromatography on silica gel (eluent: cyclohexane/ethyl acetate 1:4) to give Compound No. B2 of Table B (328 mg, 74% yield) and Compound No. C1 of Table C (18 mg, 4% yield).

出典