反応 #1340567

反応方程式

dibenzo[f,h]quinoxaline

hexane

n-butyllithium

3-bromofluorobenzene

→

2-(3-Fluorophenyl)-dibenzo[f,h]quinoxaline

収率 23.0%

溶媒

dichloromethane

Water

tetrahydrofuran

反応条件

後処理

1. 1
   温度The mixture was heated to room temperature
2. 2
   workup.STIRRINGstirred for 12 hours with the temperature
3. 3
   温度maintained at room temperature
4. 4
   抽出was extracted
5. 5
   乾燥The obtained organic layer was dried with anhydrous magnesium sulfate
6. 6
   その他The solution obtained by the drying
7. 7
   ろ過was filtrated
8. 8
   workup.DISTILLATIONThe solvent of this solution was distilled off
9. 9
   その他by recrystallization with ethanol
10. 10
    その他was obtained (a light-orange powder, yield: 23%)
11. 11
    その他Synthesis scheme of Step 1

実験手順

First, under a nitrogen atmosphere, 27.5 mL (1.58 mol/L) of a hexane solution of n-butyllithium was dripped into a mixed solution of 6.87 g of 3-bromofluorobenzene and 40 mL of tetrahydrofuran at −78° C. Then, with the temperature maintained at −78° C., the mixture was stirred for 2 hours. To the obtained solution was added 7.54 g of dibenzo[f,h]quinoxaline in five additions at −78° C. The mixture was heated to room temperature,and stirred for 12 hours with the temperature maintained at room temperature. Water was added to this mixture and dichloromethane was used as an extraction solvent, so that an organic layer was extracted. The obtained organic layer was dried with anhydrous magnesium sulfate. The solution obtained by the drying was filtrated. The solvent of this solution was distilled off, and then, by recrystallization with ethanol, the organometallic complex of the present invention, Hdbq-3FP, which was the target substance, was obtained (a light-orange powder, yield: 23%). Synthesis scheme of Step 1 is shown in (a-2) below.

出典