反応 #1340557

反応方程式

sodium hydroxide

3-(3-trifluoromethylphenyl)propanal

(R)-1-(1-naphthyl)ethylamine

sodium triacetoxyborohydride

→

(R)—N-(3-(3-trifluoromethylphenyl)propyl)-1-(1-naphthyl)ethylamine

溶媒

acetic acid

dichloromethane

water

反応条件

後処理

1. 1
   workup.STIRRINGthe mixture had been stirred for 3 hours
2. 2
   その他the resultant was separated into an aqueous layer
3. 3
   抽出The aqueous layer was extracted with dichloromethane
4. 4
   乾燥dried over anhydrous sodium sulfate
5. 5
   濃縮concentrated under reduced pressure
6. 6
   その他The residue was purified with column chromatography (silica gel/hexane:ethyl acetate of 4:1 to 1:1)
7. 7
   濃縮concentrated

実験手順

To a mixture of 2.12 g of 3-(3-trifluoromethylphenyl)propanal synthesized in the Step 2, 2.0 ml of (R)-1-(1-naphthyl)ethylamine, 3.42 g of sodium triacetoxyborohydride, and 150 ml of dry dichloromethane was added 0.750 ml of glacial acetic acid, and the mixture was stirred at room temperature for 5 hours. After 100 ml of water had been added and the mixture had been stirred for 3 hours, 100 ml of 2M sodium hydroxide aqueous solution was added, and the resultant was separated into an aqueous layer and an organic layer. The aqueous layer was extracted with dichloromethane, and the extract was combined with the separated organic layer, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure. The residue was purified with column chromatography (silica gel/hexane:ethyl acetate of 4:1 to 1:1) and then concentrated to afford 3.41 g of (R)—N-(3-(3-trifluoromethylphenyl)propyl)-1-(1-naphthyl)ethylamine as an oil. The compound was dissolved in 10 ml of dichloromethane, 5 ml of 4M hydrochloric acid/dioxane and 20 ml of toluene were added, and the mixture was concentrated under reduced pressure to pureness. The residue was recrystallized from 40 ml of ethanol and 200 ml of heptane to afford 1.71 g of the captioned compound.

出典