反応 #1331511

反応方程式

[3-Methoxymethyl-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl]-methyl-(tetrahydro-pyran-4-ylmethyl)-amine

HCl

→

[2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl]-methyl-(tetrahydro-pyran-4-ylmethyl)-amine

収率 55.0%

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated
2. 2
   その他adjusted to pH 10 with ammonium hydroxide (25%), whereupon a precipitation
3. 3
   その他formed
4. 4
   その他The precipitation
5. 5
   ろ過was filtered
6. 6
   洗浄the crystals washed with water
7. 7
   その他After drying in vacuo

実験手順

0.03 g [3-Methoxymethyl-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl]-methyl-(tetrahydro-pyran-4-ylmethyl)-amine (0.056 mmol) were treated with 5N HCl (1 ml) at 90° C. for 0.5 h. The reaction mixture was concentrated, taken up in water (1 ml) and adjusted to pH 10 with ammonium hydroxide (25%), whereupon a precipitation formed. The precipitation was filtered, the crystals washed with water. After drying in vacuo, 0.015 g [2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl]-methyl-(tetrahydro-pyran-4-ylmethyl)-amine (55%) was obtained as a yellow solid; M.p.: 190–195° C.

出典