反応 #1328423

反応方程式

methyl 5-chloro-4-oxothiochromane-8-carboxylate

N,N-dimethylformamide dimethyl acetal

→

methyl 5-chloro-3-(N,N-dimethylaminomethylidene)-4-oxothiochromane-8-carboxylate

収率 97.0%

反応条件

後処理

1. 1
   workup.DISTILLATIONVolatile components were then distilled off
2. 2
   洗浄the organic phase was washed with water
3. 3
   その他Drying
4. 4
   その他removal of the solvent

実験手順

30 g (0.078 mol) of methyl 5-chloro-4-oxothiochromane-8-carboxylate in 300 ml of N,N-dimethylformamide dimethyl acetal were refluxed for 6 hours. Volatile components were then distilled off, the residue was taken up in methylene chloride and the organic phase was washed with water. Drying and removal of the solvent gave 35.3 g (97%) of methyl 5-chloro-3-(N,N-dimethylaminomethylidene)-4-oxothiochromane-8-carboxylate.

出典